CLINICAL AND EPIDEMIOLOGICAL FEATURES OF COMPLEX APPROACHES IN THE TREATMENT OF OSTEOPOROSIS IN SYSTEMIC SCLERODERMA
Keywords:
Osteoporosis, systemic scleroderma, vasculopathy, cellular, humoral autoimmune, densitometry, simple venipuncture, hormonal, diabetes mellitus, pregnancy.Abstract
Diseases of osteoporosis and the assessment of the patient is taken from the degree of fracture as a marker of many diseases. But bone mineral density (SMZ) is also associated with disease and the risk of fracture. Metabolic disorders associated with secondary osteoporosis are 2-3 times higher in women and in men with hip fractures and vertebral fractures. Globally, osteoporosis is the most common metabolic, bone disease, affecting more than 200 million people worldwide. In Europe, the United States and Japan, 75 million people are diagnosed with osteoporosis. As SMZ decreases, osteoporosis increases with age. Senile osteoporosis is more common in people over 70 years of age. Secondary osteoporosis can occur in any person. Although bone loss in women begins gradually, it accelerates menopause, with delivery at age 50 and beyond. The incidence of postmenopausal osteoporosis is highest in 50-70 women. Women are higher on osteoporosis. Half of postmenopausal women have fractures associated with life and osteoporosis; Ush develops a spinal deformity in 25% of women, and 15% experience hip fractures. Hip fractures are similar in different ethnicities.
References
Tsou P.S, B. J. Rabquer, R. A. Ohara / Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines // Rheumatology (Oxford, England)-2016.Vol.55-P.745–754.
Vasikaran S, Eastell R, Bruye`re O, Foldes AJ, Garnero P, Griesmacher A / Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treat-ment: a need for international reference standards // Osteoporos Int-2004.Vol.22-P.391–420.
Vacca A, Cormier C, Piras M, Mathieu A, Kahan A, Allanore Y / Vitamin D deficiency and insufficiency in 2 independent cohorts of patients with systemic sclerosis // J Rheumatol-2009.Vol.36-P.1924–1929.
Van Etten E, Mathieu C / Immunoregulation by 1, 25-dihydroxy vitamin D3: basic concepts // J Steroid Biochem Mol Biol-2005.Vol.97-P.93–101.
Van Halteren AG, Tysma OM, van Etten E, Mathieu C, Roep BO // 1alpha, 25-dihydroxyvitamin D3 or analogue treated den-dritic cells modulate human autoreactive T cells via the selective induction of apoptosis // J Autoimmun-2004.Vol.23-P.233–239.
Vacca A, Cormier C, Piras M, Mathieu A, Kahan A, Allanore Y / Vitamin D deficiency and insufficiency in 2 independent cohorts of patients with systemic sclerosis // J Rheumatol-2009.Vol.36-P.1924–1929.
Van den Hoogen F, Khanna D, Fransen J / 2013 classi-fication criteria for systemic sclerosis: an American College of RheumatologyEuropean League against Rheumatism collaborative initiative // Arthritis Rheum-2013.Vol.65-P.2737–2747.
Weinhold B, R uther U / Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene // Biochem J-2011.Vol.327-P.425–429.
Wiersinga WM/Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease // Endocrinol Metab-2016.Vol.31-P.213–222.
Willis BC, Liebler JM, Luby-Phelps K/Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis // Am J Pathol-2015.Vol.166-P.1321–1332.
Wan YN, Zhang L, Wang YJ, Yan JW, Wang BX, Wang J / The association between systemic sclerosis and bone mineral density: a meta-analysis of observational studies // Int J Rheum Dis-2017.Vol.17-P.845–855.
Wöbke TK, Sorg BL, Steinhilber D / Vitamin D in inflammatory diseases // Front Physiol-2014.Vol.5-P.244.
Yuen SY, Rochwerg B, Ouimet J / Patients with scleroderma may have increased risk of osteoporosis. A comparison to rheumatoid arthritis and noninflammatory musculoskeletal conditions // J Rheumatol-2008.Vol.35-P.1073–1078.
Zheng SX, Vrindts Y, Lopez M / Increase in cytokine production (IL-1 beta, IL-6, TNF-alpha but not IFN-gamma, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis // Maturitas-2011.Vol.26-P.63–71.
Zhang L, Duan Y, Zhang TP / Association between the serum level of vitamin D and systemic sclerosis in a Chinese population: a case control study // Int J Rheum Dis-2016.Vol.3-P.11-13.
