NEW VIEWS ON ETIOLOGY AND PATOGENESIS OF AVASCULAR NECROSIS OF FEMORAL HEAD IN PATIENTS WITH COVID 19
Keywords:
Avascular necrosis of femoral head,alcoxol,dexametason,Abstract
Avascular necrosis of the femoral head(ANFH) is the necrosis of areas of the bone marrow of the femoral head with the development of local osteoporosis and osteonecrosis due to blood supply disorders. It is manifested by increasing pain, limited movement, and impaired hip joint function. It can cause disability of the patient.
Materials and methods:scientific articles and Internet resources were used for this study, in particular,such databases as CyberLeninka and PubMed were used.
Discussion. The causes and pathogenesis of osteonecrosis in nontraumatic cases are not fully understood. The most likely causes of the development of this disease were a combination of several causes: a previous coronavirusinfection; treatment with (dexamethasone); previously existingand undiagnosed osteopenia; vitamin D deficiency.The relationship of ANFH development with a previous coronavirus infection is beyond doubt, since complaints
of pain in the right TBS have a chronologicalconnection with COVID-19, before which, the patient led an active lifestyle and did not experience any pain.
References
Cipollaro L, Giordano L, Padulo J, Oliva F, Maffulli N. Musculoskeletal symptoms in SARS-CoV-2 (COVID-19) patients. J Orthop Surg. 2020;15(1):178. doi: 10.1186/s13018-020-01702-w
Agarwala SR, Vijayvargiya M, Pandey P. Avascular necrosis as a part of ‘long COVID-19. BMJ Case Rep. 2021;14(7):e242101. doi: 10.1136/bcr-2021-242101
Bagaria V. Usual and unusual musculoskeletal sequalae of COVID 19! Indian J Orthop. 2021;55(S2):518-519. doi: 10.1007/ s43465-021-00412-7
Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, Santulli G. Hypertension, thrombosis, kidney failure, and diabetes: Is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. J Clin Med. 2020;9(5):1417. doi: 10.3390/jcm9051417
Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. 2002;3(6):889-901. doi: 10.1016/s1534- 5807(02)00369-6
Hasan LK, Deadwiler B, Haratian A, Bolia IK, Weber AE, Petrigliano FA. Effects of COVID-19 on the musculoskeletal system: Clinician’s guide. Orthop Res Rev. 2021;13:141-50. doi: 10.2147/ORR.S321884
Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998;102(2):274-282. doi: 10.1172/JCI2799
O’Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, et al. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology. 2004;145(4):1835-1841. doi: 10.1210/en.2003-0990
Weinstein RS, Chen J-R, Powers CC, Stewart SA, Landes RD, Bellido T, et al. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest. 2002;109(8):1041-1048. doi: 10.1172/JCI14538
Weinstein RS, Wan C, Liu Q, Wang Y, Almeida M, O’Brien CA, et al. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell. 2010;9(2):147-161. doi: 10.1111/j.1474-9726.2009.00545.x
Clinical and radiographic outcomes after femoral varus derotation osteotomy for Legg-Calvé-Perthes disease at 25 years follow-up: what are the determinants of outcome in the long term? / B.K. Aydin, H. Sofu, M.N. Konya, T. Er, V. Sahin // Hip Int. 2016. Vol. 26, No 3. P. 301-306. DOI: 10.5301/HIPINT.5000329
Catto M. Pathology of aseptic bone necrosis. In: Aseptic Necrosis of Bone / Ed. by Davidson J.K. Amsterdam: Excerpta Medica. 1976. P. 3-100.
Joʻraboyeva Gulhayyo Baxtiyor Ранняя диагностика патологии при ревматоидном артрите. The American Journal of Medical Sciences and Pharmaceutical. 2021. Issue: 08 Pages: 21-25.
Davlatov Sh.Q., Saydaxmedov Z.I., Mahmudov U.I. CLINICAL AND FUNCTIONAL STATUS OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH COVID-19. SCIENTIFIC ASPECTS AND TRENDS IN THE FIELD OF SCIENTIFIC RESEARCH: a collection scientific works of the International scientific online conference (30th December, 2023) – Poland, Warsaw : "CESS", 2023. 16 (151), 50-53
Saydaxmedov, Z. I., & Mahmudov, U. I. (2023). Dynamics Of Glycemic Variability In Patients With Type 2 Diabetes Mellitus During Deprescribing Therapy Depending On The Presence Of Severe Comorbid Pathology. Innovative Developments And Research In Education, 2(24), 243-249.
Mamlakat, Y., & Kamola, N. (2022). Postcovid syndrome: arterial hypertension. European journal of modern medicine and practice, 2(3), 135-138.
Shermatov, R. M. ., Nishanova, Z. X. ., Nasirdinov, M. Z., Ogli Xabibullayev, S. R. ., & Bobojonov, S. S. U. . (2021). The Content Of Vitamin D Metabolites In Rachit In Children Of Early Age Who Received Specific Prevention. The American Journal of Medical Sciences and Pharmaceutical Research, 3(06), 131–138. https://doi.org/10.37547/TAJMSPR/Volume03Issue06-21
Lucey M.R., Mathurin P., Morgan T.R. Alcoholic hepatitis // N. Engl. J. Med. 2009. Vol. 360, No 26. P. 2758-2769. DOI: 10.1056/NEJMra0805786
Goldblatt J., Sacks S., Beighton P. The orthopedic aspects of Gaucher disease // Clin. Orthop. Relat. Res. 1978. No 137. P. 208-214.
Zhang N-F, Li ZR, Wei H-Y, Liu Z-H, Hernigou P. Steroidinduced osteonecrosis: The number of lesions is related to the dosage. J Bone Joint Surg Br. 2008;90-B(9):1239-1243. doi: 10.1302/0301-620X.90B9.20056
Aaron RK, Voisinet A, Racine J, Ali Y, Feller ER. Corticosteroidassociated avascular necrosis: dose relationships and early diagnosis: Ann N Y Acad Sci. 2011;1240(1):38-46.
Guo KJ, Zhao FC, Guo Y, Li FL, Zhu L, Zheng W. The influence of age, gender and treatment with steroids on the incidence of osteonecrosis of the femoral head during the management of severe acute respiratory syndrome: A retrospective study. Bone Jt J. 2014;96-B(2):259-262. doi: 10.1302/0301-620X.96B2.31935
Zhang B, Zhang S. Corticosteroid-induced osteonecrosis in COVID-19: A call for caution. J Bone Miner Res. 2020;35(9): 1828-1829. doi: 10.1002/jbmr.4136
Shetty GM. Double trouble – COVID-19 and the widespread use of corticosteroids: Are we staring at an osteonecrosis epidemic? Indian J Orthop. 2022;56(2):226-236. doi: 10.1007/s43465-021- 00546-8
Mahmudov, U. I. (2023). COMPARATIVE CHARACTERISTICS OF CLINICAL AND LABORATORY PARAMETERS OF PATIENTS OF THE DIABETIC FOOT DEPARTMENT, DEPENDING ON THE PRESENCE OR ABSENCE OF DIABETES MELLITUS. SO ‘NGI ILMIY TADQIQOTLAR NAZARIYASI, 6(12), 355-360.
Khodjayeva Gulnora Abdubannonovna NOVATEUR PUBLICATIONS JournalNX- A Multidisciplinary Peer ReviewedJournal ISSN No: 2581 - 4230 VOLUME 9, ISSUE 10, October -2023 CLASSIFICATION OF ABDOMINAL TUBERCULOSIS
THE RELATIONSHIP BETWEEN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND CARDIOVASCULAR DISEASE (CVD) Davlatov Shohjaxonbek Qurbonbek o'g'li Fergana Public Health Medical Institute 6-TOM / 12-SON / 2023-YIL / 15-DEKABR (93-104)
Intracapsular pressure in transient synovitis of the hip / H. Wingstrand, N. Egund, N.O. Carlin, L. Forsberg, T. Gustafson, G. Sundén // Acta Orthop. Scand. 1985. Vol. 56, No 3. P. 204-210. DOI: 10.3109/17453678508992995
Guerado E., Caso E. The physiopathology of avascular necrosis of the femoral head: an update // Injury. 2016. Vol. 47, No Suppl. 6. P. S16-S26. DOI: 10.1016/S0020- 1383(16)30835-X
